DMT (N,N-Dimethyltryptamine)

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DMT (N,N-Dimethyltryptamine) is the prototypical indolethylamine hallucinogen. The history of human experience with DMT probably goes back several hundred years since DMT usage is associated with a number of religious practices and rituals. As a naturally occurring substance in many species of plants, DMT is present in a number of South American snuffs and brewed concoctions, like Ayahuasca. In addition, DMT can be produced synthetically. The original synthesis was conducted by a British chemist, Richard Manske, in 1931. DMT gained popularity as a drug of abuse in the 1960s and was placed under federal control in schedule I when the Controlled Substances Act was passed in 1971. Today, it is still encountered on the illicit market along with a number of other tryptamine hallucinogens.Like other indolethylamine hallucinogens, DMT consists of the tryptamine core structure (left, structure below). DMT is formed by substituting two methyl (CH3) groups for the two hydrogen atoms (H) on the terminal nitrogen of the ethylamine side chain of tryptamine.DMT is used for its psychoactive effects. The intense effects and short duration of action are attractive to individuals who want the psychedelic experience but do not choose to experience the mind altering perceptions over an extended period of time as occurs with other hallucinogens, like LSD. DMT is generally smoked or consumed orally in brews like Ayahuasca.

N,N-dimethyltryptamine (DMT) is a hallucinogen found endogenously in human brain that is commonly recognized to target the 5-hydroxytryptamine 2A receptor or the trace amine-associated receptor to exert its psychedelic effect. DMT has been recently shown to bind sigma-1 receptors, which are ligand-regulated molecular chaperones whose function includes inhibiting various voltage-sensitive ion channels. Thus, it is possible that the psychedelic action of DMT might be mediated in part through sigma-1 receptors. …The psychotomimetic agent dimethyltryptamine (DMT) has been identified as an endogenous compound in the central nervous system of rodents using a sensitive electron capture gas chromatographic technique. DMT along with its proposed precursor, tryptamine, were identified and quantitated as the heptafluorobutyryl derivatives. A specific high affinity binding site on synaptosomal membranes has been proposed for DMT.

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